Improvement of Skeletal and Muscle Health in Patients With Sarcopenia by Protein Powder With Resistance Exercise

Launched by WEIWEI MA · Jun 25, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a special protein powder combined with gentle strength exercises can help improve muscle and bone health in people with sarcopenia, a condition where muscles become weak and smaller as we age. The protein powder includes milk protein and other ingredients like vitamin D and nutrients that may help reduce inflammation and support muscle health. The study aims to see if this combination can better improve muscle strength, bone density, and even gut health compared to exercise alone.

People who might join this study are between 35 and 75 years old and have been diagnosed with sarcopenia based on tests measuring muscle strength, walking speed, and muscle mass. Participants should be willing and able to follow the study’s program and give informed consent. Those with serious health problems, allergies to protein powder, recent fractures or surgeries, or other conditions affecting muscles may not be eligible. If you join, you can expect to take the protein powder and do low-intensity resistance exercises while researchers monitor changes in your muscle and bone health over time. This study hopes to find better ways to help people with muscle loss stay stronger and healthier as they age.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Meet the diagnostic criteria for sarcopenia AWGS 2019
• • 1. Grip strength less than 28.0 kg for males and less than 18.0 kg for females
• • 2. 6-meter stride speed less than 1.0 m/s or 5-repetition sit-up test time ≥ 12 seconds or SPPB ≤ 9 points.
• • 3. Bioelectrical Impedance Analysis (BIA) less than 7.0 kg/m² for males and 5.7 kg/m² for females or Dual-energy X-ray absorptiometry (DXA) less than 7.0 kg/m² for males and 5.4 kg/m² for females;
• • Age between 35-75 years old with high compliance;
• • Complete clinical data;
• • Voluntary participation in the program with informed consent and signing of the informed consent form.
• Exclusion Criteria:
• • A clear history of allergy to protein powder in the past 6 months, or the presence of diarrhea symptoms and the frequency of ≥ 7 days / month, the duration of more than 2 weeks;
• • Major physical diseases (diabetes with serious complications, malignant tumors, serious cardiovascular disease, neurological diseases or other diseases that may affect the effectiveness of exercise and nutritional interventions, etc.);
• • The past three months, new fractures and recently underwent joint replacement surgery patients;
• • Suffering from congenital bone or muscle diseases;
• • The simultaneous existence of other comorbidities affecting muscle metabolism, such as malignant tumors, liver disease, severe organ insufficiency such as nephrotic syndrome, renal failure and other diseases that may affect protein metabolism;
• • Participating in other clinical trials patients;
• • With sensory disabilities or other reasons significantly affecting the collection of data, such as severe deafness, blindness, mental disorders, etc.;
• • The researchers The researchers believe that other reasons are not suitable for clinical trials.