The Effect of Simulated Burn Injury on Post Exercise Recovery in a Hot Environment

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Jun 25, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how people’s bodies cool down after exercise in hot weather, especially when part of their skin acts like it has a burn injury. People who have had burns often have trouble regulating their body temperature because the skin in the burned areas doesn’t sweat or get blood flow as well as normal skin. This study uses a special material placed on the skin to mimic a burn injury and wants to find out if this affects how quickly the body temperature returns to normal after exercising in the heat.

To join the study, participants need to be between 18 and 65 years old, generally healthy, and without serious medical conditions like heart disease, diabetes, or high blood pressure. Women who are pregnant or breastfeeding cannot participate. People who smoke, have certain medications that affect body temperature, or have a body weight above a certain level will also be excluded. During the study, participants will exercise in a warm environment, both with and without the simulated burn material on their skin, so researchers can compare how their bodies cool down afterward. This research could help improve safety and recovery strategies for burn survivors when they exercise or are active in hot conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants will be 18 and 65 years of age and must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.
• Exclusion Criteria:
• • Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc.; as well as serious abnormalities detected on routine screening. Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test. Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response will likewise be an exclusion. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants will also be excluded if body mass index is ≥ 31 kg/m2.