Laser Posterior Nasal Nerve Neurolysis

Launched by CHIAYI CHRISTIAN HOSPITAL · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called laser posterior nasal nerve neurolysis to see if it can help adults who have chronic rhinitis—a condition that causes long-lasting nasal allergy symptoms like a runny nose, sneezing, stuffiness, and congestion that don’t get better with regular medicines. The study also wants to find out if this laser treatment is safe and what side effects it might cause. To do this, researchers will compare the laser treatment to a fake procedure (called a placebo) that feels the same but doesn’t actually use the laser, to see if the real treatment works better.

People who might be eligible for this study are adults between 18 and 65 years old who have had bothersome nasal allergy symptoms for at least six months and haven’t found relief with standard medications like nasal sprays and allergy pills. If they join, participants will have the laser treatment done in the doctor’s office with local numbing medicine, so they won’t feel pain. They will then come back for check-ups at 1 week, 1 month, and 3 months after the treatment to see how their symptoms are doing. They will also be asked to rate their symptoms before and after the treatment to help researchers understand if the laser therapy is effective. This study is currently looking for volunteers, and anyone interested should make sure they don’t have certain conditions that might make the procedure unsafe, like recent sinus infections or previous nasal surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 18 and 65 years old
• • Chronic rhinitis symptoms for at least 6 months that have not responded effectively to medication (should include at least Intranasal corticosteroid (ICS) combined with intermittent use of oral antihistamine and, as needed, combination nasal spray) or where medication has not provided sustained improvement
• • Total rTNSS ≥ 5 with Moderate to severe rhinorrhea symptoms (24-hour reflective Total Nasal Symptom Score \[rTNSS\] rhinorrhea score of 2-3) and mild to severe nasal congestion symptoms (rTNSS nasal congestion score of 1-3)
• • All enrolled patients routinely undergo endonasal endoscopic examination, or have had a sinus CT within the past month confirming no significant rhinosinusitis."
• Exclusion Criteria:
• • Obstructive anatomical abnormalities limiting access to posterior nasal passages
• • Nasal anatomical changes due to previous sinus or nasal surgery or injury
• • Ongoing nasal or sinus infection
• • History of severe dry eye, chronic epistaxis, rhinitis medicamentosa, or head and neck radiotherapy
• • Self-reported history of bleeding tendency
• • Current use of anticoagulants with inability to discontinue
• • Previous chronic rhinitis surgery
• • History of poor wound healing after head, neck, or throat surgery