COVID-19 Reactogenicity

Launched by MARCEL CURLIN · Jul 1, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how people react after getting two different COVID-19 vaccines: the Novavax vaccine, which is protein-based, and the Pfizer vaccine, which uses mRNA technology. The study wants to find out how often people experience side effects or symptoms after vaccination with each type. This information can help us understand more about the safety and comfort of these vaccines.

Adults aged 18 and older who are eligible for the seasonal COVID-19 vaccine and have already received at least one COVID-19 vaccine may be able to join. Before participating, they will need to give their permission by signing a consent form. People who are currently sick with a fever, have had serious allergic reactions to COVID-19 vaccines before, or have certain heart inflammation issues related to COVID-19 vaccines will not be able to take part. Participants should also not have received any other vaccines within a week before or after joining the study. If you join, you can expect to report any symptoms you experience after getting the vaccine, helping researchers compare how people respond to these two types of vaccines.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults eligible for seasonal COVID-19 vaccine, ages 18 and older Signed informed consent form (ICF) and agree to participate in the study Prior receipt of one or more COVID-19 vaccines
• Exclusion Criteria:
• • If a person is experiencing a moderate or severe illness or infection (as judged by the study investigator) or has a fever (temperature of 38.0°C or higher) on the day they are supposed to participate in the study, they should not join until they are feeling better and the fever is gone.
• • Anyone with a medical or mental health issue, or problems with substance use that might make taking part in the study risky
• • People who have had a severe allergic reaction to COVID-19 vaccines in the past
• • Those who have been diagnosed with inflammation in or around the heart after receiving a COVID-19 vaccine
• • Individuals who have received any other vaccine within a week before joining the study or who plan to get a vaccine on the same day as the study or within 7 days afterward