Impact of Interventional Endoscopy on Quality of Life in Patients With Acute Respiratory Distress Due to Tumor Compression or Obstruction of the Lower Respiratory Tract
Launched by UNIVERSITY HOSPITAL, GRENOBLE · Jun 26, 2025
Trial Information
Current as of July 12, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how a special procedure called interventional endoscopy affects the quality of life for patients who have breathing problems caused by tumors blocking or pressing on the airways in the lungs. This procedure uses a thin, flexible tube with a camera and tools to help open up or support the airways, which can improve breathing. The study will look at how patients feel one week after the procedure compared to before, focusing on their breathing and overall well-being.
Adults over 18 years old who have solid tumors causing blockage or pressure in their airways and are experiencing serious breathing difficulties may be eligible to join. To take part, patients need to be able to understand and answer questions about their health and should not have any legal guardians managing their care. If selected, participants will undergo the endoscopy treatment and be asked to complete a questionnaire about their breathing and quality of life before and after the procedure. This study aims to help doctors better understand how this treatment can improve daily life for patients with tumor-related breathing problems.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • \>18 years old
- • tumoral tracheobronchial obstruction and/or compression
- • proven solid cancer or suspicion
- * Acute respiratory distress (at least one of the 5):
- • RR : ≥25/min
- • Sign of respiratory struggle
- • Sign of respiratory failure
- • Oxygen therapy ≥5L/min
- * Ventilatory support (NIV, OHD or IT) :
- • Indication for therapeutic interventional endoscopy
- • No guardianship or curatorship
- • Non-hematological tumor
- Exclusion Criteria:
- • Minors
- • patients with neurological disabilities unable to understand and respond to the questionnaire
- • patients under guardianship or curatorship
About University Hospital, Grenoble
The University Hospital of Grenoble is a leading academic medical center dedicated to advancing healthcare through innovative clinical research and comprehensive patient care. As a prominent sponsor of clinical trials, the hospital leverages its expertise in various medical disciplines to facilitate cutting-edge studies that aim to improve treatment outcomes and enhance patient safety. With a strong commitment to collaboration, the University Hospital of Grenoble engages in partnerships with academic institutions, industry leaders, and regulatory bodies to drive scientific discovery and translate research findings into clinical practice. Its state-of-the-art facilities and multidisciplinary teams ensure rigorous adherence to ethical standards and regulatory guidelines, fostering an environment where groundbreaking research can thrive.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported