Deep Learning-Based Confocal Laser Microendoscopy Feature Atlas Construction and Its Application in Intelligent Diagnosis of Irritable Bowel Syndrome

Launched by DAPING HOSPITAL AND THE RESEARCH INSTITUTE OF SURGERY OF THE THIRD MILITARY MEDICAL UNIVERSITY · Jun 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help diagnose Irritable Bowel Syndrome (IBS) using advanced imaging technology and computer analysis. Researchers will compare detailed images of the gut lining from people with IBS and healthy individuals, using a special camera called confocal laser endomicroscopy during a colonoscopy. They will then use a computer program that learns patterns from these images to create a model that can help identify IBS more accurately. This could make diagnosing IBS easier and more precise in the future.

People eligible for this study are adults aged 18 to 80 who either have a clear diagnosis of IBS based on standard criteria or are healthy with no gut symptoms. Participants will undergo a colonoscopy procedure, where the doctor uses a tiny camera to look inside the colon. During this, the special imaging will take close-up pictures of the bowel lining. For those with IBS, small tissue samples may also be taken for further testing. Participants need to be able to safely have these procedures, including having normal blood clotting and no allergies to the dyes used. If you qualify and join, you can expect a careful and detailed examination aimed at better understanding IBS, which may help improve diagnosis for many people in the future.

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Eligibility criteria

• Inclusion Criteria:
• • ①Healthy control group and test group of IBS with clear clinical diagnosis (Rome IV diagnostic criteria). Healthy controls are free of gastrointestinal symptoms, test results (blood count, CRP, ESR, etc.) and colonoscopy abnormalities.Patients with IBS have recurrent abdominal pain (≥1 day per week on average in the past 3 months), with onset ≥6 months before diagnosis, and the abdominal pain is accompanied by at least two of the following three symptoms: pain related to defecation, change in stool frequency, and change in the shape (appearance) of the feces, and other organic or metabolic disorders are excluded.② Age: between 18 and 80 years old.③ Probe-based confocal Laser Endomicroscopy (pCLE) is required, and patients have good compliance. ④ Normal coagulation function, and biopsies can be obtained for pathological examination.⑤ Voluntary signing of informed consent.
• Exclusion Criteria:
• • Fluorescein sodium allergy. ②Contraindications to colonoscopy (pregnant or breastfeeding patients, uncooperative psychiatric patients with severe mental disorders, colonic obstruction) or inadequate bowel preparation (Boston Bowel Preparedness Scale score of \<2 for any colonic segment).③ Comorbidities with major organ dysfunction (with severe cardiopulmonary disease) or impaired renal function (blood creatinine \>450umol/L). ④ Other conditions that, in the judgment of the investigator, make it unsuitable for participation in the study (inflammatory bowel disease, infected IBS, having taken nonsteroidal anti inflammatory drugs, corticosteroids or antibiotics within the last year, etc.).