Systematic Adjunction of Vasopressine in Septic Shock

Launched by ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE · Jun 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether adding a medicine called vasopressin to the usual treatment with norepinephrine can help people who have septic shock—a serious condition caused by a severe infection that leads to dangerously low blood pressure. Normally, norepinephrine is the first medicine used to raise blood pressure in these patients, but high doses can be linked to worse outcomes. Researchers want to see if giving vasopressin alongside norepinephrine early on can improve survival, especially in patients whose hearts are still pumping well but who need help maintaining blood pressure.

People eligible to join this study are adults aged 18 or older who are in septic shock and have been on a certain dose of norepinephrine for less than 12 hours. To participate, patients or their close family members must agree to take part. Some patients, like those with recent heart problems, very low sodium levels, or allergies to vasopressin, cannot join. If you take part, doctors will carefully add vasopressin to your treatment and monitor how it affects your condition. This study is not yet recruiting, but its goal is to find better ways to treat septic shock and improve chances of recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient aged 18 or over
• • Patient who has consented to take part in the research or patient whose close relative has consented to take part in the research or, failing that, patient being included in an emergency situation
• • Patient in septic shock with adapted cardiac output
• • Patient in whom noradrenaline dosage has been greater than 0.3μg/kg/min for less than 12 hours
• • Patients benefiting from or affiliated to social security
• Exclusion Criteria:
• • Patient with acute coronary syndrome
• • Patient with known history of acute coronary syndrome
• • Patient with suspected mesenteric ischemia
• • Patient with hyponatremia \< 130mmol/L,
• • Known allergy to vasopressin or its excipients
• • Minors
• • Pregnant women
• • Patients under legal guardianship or curatorship
• • Patients under judicial protection.