Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction

Launched by CROATIAN SOCIETY FOR ORGAN SUPPORT · Jul 1, 2025

Keywords

ClinConnect Summary

This clinical trial, called the KARMA study, is looking at different ways to support patients whose kidneys have suddenly stopped working, a condition known as acute kidney injury. When this happens, especially in very sick patients in the intensive care unit (ICU), machines called continuous renal replacement therapy (CRRT) are used to help filter and clean the blood. The study wants to find out if starting this treatment earlier or later, using different amounts of treatment, or choosing different types of machines can help patients’ kidneys recover more quickly and avoid long-term kidney problems.

The study is open to adults aged 65 to 74 who are experiencing acute kidney injury while in the ICU. People who already have severe chronic kidney disease or who are on long-term dialysis won’t be able to join. If you take part, the doctors will use one of several treatment approaches with the blood-filtering machines and closely watch how your kidneys respond. By gathering information from many patients across different hospitals, this research hopes to improve future care for people with sudden kidney problems. The study is not yet recruiting participants but aims to help patients regain kidney health faster in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute kidney injury
• • ICU administration
• Exclusion Criteria:
• • Pre-existing CKD (GFR \< 30 ml/min/1,73m2)
• • Chronic dialysis-dependent end-stage renal failure