Curcumin, Vitamin D and Green Tea in IBS-D

Launched by DR ANTHONY HOBSON · Jul 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a combination of three natural supplements—green tea, vitamin D, and curcumin (a compound found in turmeric)—can help improve symptoms in people with a type of irritable bowel syndrome (IBS) that mainly causes diarrhea, called IBS-D. IBS is a common digestive condition that can significantly affect daily life, and currently, there aren’t many effective treatments for the diarrhea type. Researchers want to see if taking these supplements together works better than a placebo (a harmless pill with no active ingredients).

The study is looking for adults aged 18 and older who have been diagnosed with IBS-D and have moderate to severe symptoms. If you join, you’ll first go through a 2-week screening period to confirm your eligibility. Then, for 4 weeks, you’ll be randomly assigned to take either the supplement combination or a placebo, without knowing which one you’re getting. After that, everyone will take the active supplements for another 4 weeks. Throughout the study, you’ll be asked to keep track of your symptoms and follow a stable diet and medication routine. This study aims to find out if these natural supplements can provide relief for IBS-D symptoms safely and effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Participant has provided written informed consent before participating in the study after being given a full description of the study and prior to any study-specific procedures being performed.
• • 2. Participant has irritable bowel syndrome with diarrhoea (IBS-D), as defined by the Rome IV criteria.
• • 3. Participant has an IBS-SSS score of \>175 at screening.
• • 4. Participant is a male or non-pregnant female and is ≥18 years of age
• • 5. Participant can communicate well with the Investigator and to comply with the requirements for the entire study.
• • 6. Participant has capacity to understand written English.
• • 7. Participant has a body mass index (BMI) of 18.5 - 39.9kg/m2 (bounds included).
• • 8. Participant agrees to follow all pre-test preparation before breath testing visits.
• Exclusion Criteria:
• • 1. Prior abdominal surgery other than appendectomy and cholecystectomy.
• • 2. Known hypercalcaemia.
• • 3. Participating in another trial or taken an IMP within the last 1 month.
• • 4. Females who report to be pregnant or lactating
• • 5. Unwilling to maintain stable doses of permitted concomitant medication
• • 6. Unwilling to maintain a stable diet for the duration of the trial
• • 7. Being in the opinion of the investigator unsuitable
• • 8. Insufficient knowledge of English to complete the daily bowel diary and food diary
• • 9. Hypersensitivity to any component of the supplement
• • 10. Hypersensitivity or known allergy to lactulose
• • 11. Drug interactions with any component of the supplement
• • 12. Consumption of antibiotics, prebiotics or probiotics (in food products or as supplements) in the last 4 weeks prior to, or during the study.
• • 13. Vitamin D two week washout
• • 14. Participants who have received bowel preparation for investigative procedures in the 4 weeks prior to the study
• • 15. Individuals declaring additional specific dietary needs
• • 16. Inflammatory bowel disease or coeliac disease
• • 17. Any other condition, deemed by the investigator, that may be causing their symptoms
• • 18. No major co-morbidity.
• • 19. Participant is involved in this study as an Investigator, sub-Investigator, study coordinator, other study staff, or Sponsor member.