Investigation of a New Window Into Intracranial Pressure: Venous Occlusion Pressure of the Isolated Periorbital Vein

Launched by UNIVERSITY OF FREIBURG · Jul 1, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new, non-invasive way to estimate the pressure inside the skull, called intracranial pressure (ICP). Normally, measuring this pressure requires invasive procedures that can be uncomfortable and carry some risks. This study looks at whether measuring the pressure in a small vein near the eye can give similar information without the need for these invasive methods. The goal is to see if this easier and safer approach can help doctors better monitor patients with conditions affecting brain pressure.

People who might be eligible for this study are adults aged 18 to 95 who need routine testing of their spinal fluid pressure as part of their medical care. Participants should not have recent brain injuries, certain surgeries, or conditions affecting the area around the eye. If they join, participants will have their eye vein pressure measured and this will be compared to the usual spinal fluid pressure tests they are already having. This study could help make monitoring brain pressure safer and more comfortable in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Medical indication to perform routine craniospinal CSF dynamic testing according to standard operative procedures
• • Aged 18-95
• • Willing and able to provide valid signed informed consent
• Exclusion Criteria:
• • Patients with any known ongoing, or history of, abnormal CSF communication
• • Patients with any kind of prior intervention for CSF diversion
• • Patients with acute brain damage within the preceding 6 months
• • Patients with transdural surgery within the preceding 6 months
• • Head wounds or hematoma that could hinder access to measurement site
• • Any known pathological condition linked to the orbital socket influencing venous outflow