Changes in Bruxism Activity After Periodontal Treatment in Patients With Periodontitis
Launched by UNIVERSITY OF SIENA · Jun 27, 2025
Trial Information
Current as of July 12, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether treating gum disease (called periodontitis) can help reduce teeth grinding and clenching, known as bruxism, which can happen both during the day and while sleeping. The researchers will look at patients with advanced gum disease before and three months after they receive non-surgical treatment to clean and care for their gums. They want to see if this treatment can lower the amount of teeth grinding and improve gum health.
Adults between 25 and 50 years old who are generally healthy and have either advanced gum disease or healthy gums may be eligible to join. People who smoke heavily, have certain health conditions, or have had recent treatments for their gums or teeth grinding may not qualify. Participants will need to visit the clinic for assessments at the start and three months after treatment, and they should be ready to follow the study’s instructions. This study is currently looking for volunteers and may help us better understand the connection between gum health and teeth grinding.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age between 25 and 50 years
- • Good general health (ASA I or II)
- • Signed informed consent
- • Willingness to attend all study visits and follow instructions
- • For periodontitis group: diagnosis of Stage III or IV periodontitis according to the 2017 classification
- • For healthy control group: no clinical signs of periodontitis
- Exclusion Criteria:
- • Systemic diseases or medications affecting the periodontium (e.g., diabetes, immunosuppressants)
- • Antibiotic or anti-inflammatory therapy within the last 3 months
- • Periodontal treatment in the last 6 months
- • Smoking more than 10 cigarettes/day
- • Use of occlusal splints or bruxism-targeted therapy in the past 6 months
- • Pregnancy or lactation
- • Any condition impairing the ability to cooperate or comply with the study protocol
About University Of Siena
The University of Siena, a leading academic institution in Italy, is dedicated to advancing medical research and improving patient care through innovative clinical trials. With a strong emphasis on interdisciplinary collaboration, the university leverages its extensive expertise in various fields of healthcare to design and conduct rigorous studies that address critical medical questions. Committed to ethical standards and patient safety, the University of Siena aims to translate scientific findings into practical applications, ultimately enhancing treatment options and health outcomes for diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Siena, , Italy
Patients applied
Trial Officials
Nicola Discepoli, DDS, PhD
Principal Investigator
Department of Medical Biotechnologies, University of Siena
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported