Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.

Launched by JOINTRESEARCH · Jul 2, 2025

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ClinConnect Summary

This Netherlands-based study is comparing single-dose versus multi-dose antibiotic prophylaxis (the antibiotics used around surgery) for hip and knee replacements. Researchers will look at real-world data to see if one-dose prevention works as well as the current multi-dose approach in preventing infections that might require another operation, and to understand how quickly hospitals adopt the new guideline and how costs differ between the two approaches. The study uses hospital records and national arthroplasty data, following patients over about two years, with roughly a year of follow-up after surgery.

Eligibility focuses on people having their first total hip or total knee replacement (primary procedures, not revisions). Children, adults, and older adults can be included; those having a revision joint replacement are not eligible. The study plans to enroll up to about 70,000 patients from multiple Dutch hospitals (an example site is OLVG Hospital in Amsterdam). Participation involves standard care; researchers will collect information from medical records and registries, without extra procedures for patients. The study is observational and aims to inform how safe, effective, and cost-friendly the single-dose approach might be in real practice.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Patients undergoing primary Total Hip Arthroplasty or primary Total Knee Arthroplasty
• Exclusion Criteria:
• • - Patients undergoing Revision Hip Arthroplasty or Revision Knee arhtroplasty