Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Launched by JOINTRESEARCH · Jul 2, 2025
Trial Information
Current as of July 22, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
SUMMARY Rationale: Antibiotic Stewardship (AS) is focusing on the precise use of antibiotics to enhance patient outcomes and curb antibiotic resistance. This concept is especially pertinent in the context of Prosthetic Joint Infection (PJI), a primary cause for revision hip arthroplasty (RHA) and revision knee arthroplasty (RKA). While perioperative antibiotic prophylaxis has proven to significantly reduce PJI risk, the optimal duration-whether to administer a single dose or multiple doses-remains hotly debated. When reflecting on the administration practices, a 2018 national survey indicat...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • - Patients undergoing primary Total Hip Arthroplasty or primary Total Knee Arthroplasty
- Exclusion Criteria:
- • - Patients undergoing Revision Hip Arthroplasty or Revision Knee arhtroplasty
About Jointresearch
JointResearch is a leading clinical trial sponsor dedicated to advancing medical science through innovative research and collaboration. With a strong focus on developing novel therapies and improving patient outcomes, JointResearch partners with a diverse network of healthcare professionals, academic institutions, and industry leaders. The organization employs rigorous methodologies and state-of-the-art technology to ensure the integrity and reliability of its clinical studies. Committed to ethical standards and regulatory compliance, JointResearch aims to contribute significantly to the advancement of healthcare and the betterment of patient lives worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Amsterdam, Noord Holland, Netherlands
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported