Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2

Launched by CENTRE HOSPITALIER ST ANNE · Jul 7, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different treatments for people who have severe narrowing (called stenosis) in one of the main arteries in the neck, which can increase the risk of stroke. The two treatments being compared are carotid endarterectomy (CEA), a surgery to remove the blockage, and carotid artery stenting (CAS), which uses a small tube to open the artery without surgery. Researchers want to understand which treatment is better for preventing strokes in patients who recently had symptoms like a mini-stroke or stroke caused by this artery narrowing.

To join the study, participants need to be adults who had a recent stroke or mini-stroke affecting one side of the body or vision, and have a significant narrowing (between 50% and 99%) in the affected artery. People with serious other health problems, recent surgeries, or certain medical conditions may not be able to take part. If you join, you will receive either surgery or stenting based on guidelines, and doctors will follow your health over time to see how well the treatments work in preventing future strokes and how safe they are. This study is not recruiting yet, but it aims to help doctors make better decisions about treating carotid artery narrowing in people who have had symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient age 18 years or over
• • Hemispheric or retinal transient ischemic attack or a non-disabling stroke (or retinal infarct) within 15 days before enrolment
• • Stenosis of 50% to 99% in the symptomatic carotid artery (NASCET method) for whom revascularisation is decided according to guidelines
• Exclusion Criteria:
• • Patients unwilling or unable to participate in follow-up for whatever reason
• • Preexisting disability (Modified Rankin Score ≥ 3)
• • Nonatherosclerotic carotid disease
• • Severe tandem lesions
• • Previous revascularization of the symptomatic carotid stenosis
• • History of bleeding disorder
• • Unstable angina
• • Contraindication to dual antiplatelet therapy
• • Contraindication to MRI
• • Life expectancy of less than 2 years
• • Percutaneaous or surgical intervention within 30 days before or after the study procedure
• • Stenotic lesion on arterial workup appeared as not a factor in the selection