UNITY VCS Vitreoretinal Surgery: Randomized Comparative Clinical Trial

Launched by ALCON RESEARCH · Jun 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different eye surgery systems—called UNITY VCS and CONSTELLATION—to see which one is safer and works better for treating various eye problems that affect the back part of the eye. These problems include conditions like epiretinal membrane, macular holes, vitreous floaters, and diabetic eye disease, among others. The goal is to help adults who need surgery for these eye issues by comparing these two surgical tools.

Adults between 65 and 74 years old who have a confirmed need for surgery on the back part of their eye may be eligible to join. To participate, their eye must be mostly clear except for certain issues like bleeding or floaters that require surgery. People with other serious eye or health problems, glaucoma, or those who have recently had certain types of eye surgery may not be able to join. Participants will undergo surgery using one of the two systems, and the study will carefully look at how safe and effective each system is. This trial is not yet recruiting, but it aims to improve surgical options for people with these eye conditions.

Gender

ALL

Eligibility criteria

• Key Inclusion Criteria:
• • Requires surgery for a clinically documented posterior vitreoretinal medical condition.
• • Clear ocular media except for vitreous hemorrhage and floaters undergoing surgery.
• • Other protocol-specified inclusion criteria may apply.
• Key Exclusion Criteria:
• • Presence of clinically significant ocular or systemic diseases that may interfere with study outcomes or safety.
• • Diagnosis of glaucoma or suspected ocular hypertension.
• • Recent intraocular eye surgery, other than cataract surgery, resulting in retained lens materials in the posterior segment (within the past 3-months).
• • Other protocol-specified exclusion criteria may apply.