Effect of Intradialytic Resistance Versus Aerobic Exercise on Cardiovascular System in Patients on Regular Hemodialysis

Launched by CAIRO UNIVERSITY · Jun 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how two types of exercise—resistance (like lifting weights) and aerobic (like walking or cycling)—affect sudden drops in blood pressure during hemodialysis, which is a treatment for people with severe kidney disease. These sudden drops, called intradialytic hypotension, can cause discomfort and complications during dialysis sessions. The study aims to see which type of exercise might help improve heart and blood vessel health in patients who regularly receive hemodialysis.

People who might be eligible for this study are adults aged 45 to 60 who have end-stage kidney disease and have been on regular hemodialysis for between one and five years. They should have experienced these blood pressure drops during dialysis and have a body weight within a healthy range (not too high or low). Participants should be medically stable, not currently exercising regularly, and using a specific type of dialysis access in their arm. During the study, participants will be asked to perform either resistance or aerobic exercises during their dialysis sessions. It’s important to note that certain people, such as those with serious heart or lung problems, recent hospital stays, or who are pregnant, will not be able to join the study. This research has not started recruiting yet but aims to find better ways to support patients on dialysis through exercise.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • End-stage renal disease (ESRD) or stage 5 chronic kidney disease (CKD) in which on maintenance regular HD (three sessions/week (on alternate days), for four hours/session for more than a year to five years when starting the study.
• • Both gender male and female aged from 45 to 60 years old.
• • Patients with intradialytic hypotension sudden drops of systolic pressure of more than 20 mm Hg or diastolic pressure of more than 10 mmHg.
• • Receiving hemodialysis (HD) through uncomplicated arm arteriovenous (A-V) fistula.
• • Patients with Body Mass Index (BMI): 18,5 \< 30kg/m2.
• • In a stable medical, clinical, and hemodynamic condition
• • Untrained at baseline and did not participate in any regular physical activity before.
• Exclusion Criteria:
• • Severe Chest diseases (either obstructive or restrictive).
• • Clinical signs of a severe cardiac event. (eg, severe atherosclerosis, congestive heart failure),
• • Severe psychiatric or cognitive impairment, who unable to follow comment.
• • Neurological disorders affecting respiratory muscles or any muscular dystrophies (cervical disc or bulge).
• • Patients with severe self-limiting illness (e.g., cancer).
• • Patients with Body Mass Index (BMI) \> 30kg/m2.
• • Previous renal transplantation patients.
• • Pregnant females or became pregnant during the study.
• • Patients started HD in less than a year or more than 5 years.
• • Hospitalized during the prior month.
• • Patients who were irregular in HD or not adherent to the exercise program.