Multi-centred Clinico-genetic Study of Actinic Prurigo in Thailand

Launched by CHULALONGKORN UNIVERSITY · Jul 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a skin condition called Actinic Prurigo (AP), which causes itchy rashes triggered by sunlight. The researchers want to understand how this condition shows up in Thai people and how it might be linked to certain genetic factors, especially specific markers in the immune system called HLA types. They are also interested in seeing if different genetic types affect how well treatments work. To do this, the study will compare people with AP to healthy individuals of the same age from several hospitals in Thailand.

If you are Thai, have been diagnosed with Actinic Prurigo, can read and communicate in Thai, and meet certain health criteria, you may be eligible to participate. The study involves genetic testing and clinical evaluations, and if you are receiving a medication called Thalidomide, you will need to use two forms of birth control during and after treatment for safety reasons. The trial excludes people with other similar skin conditions or certain viral infections. Overall, participants can expect to help improve understanding of AP in the Thai population, which may lead to better diagnosis and treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Thai ethnicity
• • Diagnosed with Actinic Prurigo (AP) according to the diagnostic criteria defined for this study
• • Mentally competent, able to communicate, and able to read Thai.
• • Participants receiving Thalidomide treatment must use two simultaneous methods of contraception, starting at least 4 weeks prior to initiating the medication and continuing throughout the treatment period and for at least 4 weeks after discontinuation.
• Exclusion Criteria:
• • History and physical examination findings suggestive of other photodermatoses such as Lupus erythematosus, Porphyria, or Polymorphous Light Eruption, among others.
• • Elevated Epstein-Barr Virus (EBV) viral load detected in blood testing (EBV viral load will be tested in all participants).
• • Low Minimal Erythema Dose (MED) to UVB radiation as the only abnormal finding.