TOETVA Technique Compared With Anterior Cervical Thyroidectomy (AC) in Terms of Efficacy and Safety

Launched by UNIVERSITY HOSPITAL, LILLE · Jul 3, 2025

Keywords

ClinConnect Summary

This clinical trial is comparing two different surgical methods used to remove part or all of the thyroid gland: the traditional approach called anterior cervical thyroidectomy (AC), which leaves a visible scar on the neck, and a newer technique called Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA). TOETVA is done through small cuts inside the mouth, so it avoids a neck scar. The study aims to see if TOETVA is as safe and effective as the traditional surgery while also looking closely at how it affects patients’ pain levels and quality of life, including how patients feel about the presence or absence of a scar.

The trial is open to adults aged 18 to 65 who need thyroid surgery for certain reasons, like small thyroid nodules or other thyroid conditions, and who have been evaluated and approved for either of the two surgery types. Participants should have a thyroid size under a certain limit and no previous neck surgery or serious health problems. If you join, the medical team will monitor you carefully before and after surgery to compare recovery, safety, and how you feel overall. This study is important because it will be one of the first to systematically compare these two approaches and help doctors understand whether TOETVA can become a common option for thyroid surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with a surgical indication for lobectomy or thyroidectomy
• • Estimated thyroid volume measured by ultrasonography of less than 60 mL
• • Nodules suspected to be malignant measuring less than 4 cm
• • Patient aged between 18 and 65 years old
• • Patient who has benefited from an endocrinological evaluation, with a favorable opinion for TOETVA or AC Patient who understands and accepts the need for follow-up
• • Patient who agrees to be included in the study and who signs the informed consent form
• • Patient affiliated to a healthcare insurance plan
• Exclusion Criteria:
• • Patients refusing an alternative to AC or refusing AC
• • History of cervical surgery
• • Associated parathyroid surgery
• • Identification of malignant lymph nodes
• • Presence of a severe and evolutive life threatening pathology
• • Patients with unstable psychiatric disorder, under supervision or guardianship
• • Patient who does not understand French/ is unable to give consent
• • Patient not affiliated to a French or European healthcare insurance
• • Patient who has already been included in a trial which has a conflict of interests with the present study
• • Pregnant or breast-feeding patient
• • Patient incarcerated