Association Between Qmax/eGFR Ratio and LUTS Severity in Men Over 40

Launched by MARMARA UNIVERSITY · Jun 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a specific measurement, called the Qmax/eGFR ratio, relates to the severity of urinary problems in men over 40. Qmax measures the speed of urine flow, while eGFR is a test that shows how well the kidneys are working. The goal is to see if this ratio helps explain how serious a man’s urinary symptoms are, which could help doctors better understand the connection between kidney health and urinary issues.

Men aged 40 or older who are experiencing urinary symptoms and have a certain level of kidney function may be eligible to join. Participants will be asked to do a simple urine flow test, provide a blood sample, and fill out a questionnaire about their symptoms and quality of life. People with certain conditions, like prostate cancer, recent urinary infections, or past bladder surgery, will not be able to take part. This study is not yet recruiting but aims to provide useful information for men with urinary difficulties and their healthcare providers.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male patients aged 40 years or older presenting with lower urinary tract symptoms (LUTS)
• • Able to provide informed consent
• • Willing and able to undergo uroflowmetry and blood testing
• • Able to complete the IPSS questionnaire, including the QoL item
• • Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73m²
• Exclusion Criteria:
• • History of urological surgery (e.g., prostatectomy, bladder surgery)
• • Diagnosed or suspected prostate cancer
• • Active urinary tract infection (based on clinical symptoms or urinalysis)
• • Neurological conditions affecting bladder function (e.g., Parkinson's disease, spinal cord injury)
• • Presence of an indwelling urinary catheter at enrollment
• • eGFR \< 30 mL/min/1.73m²
• • Inability to perform uroflowmetry or complete clinical evaluations