Prevention of Desaturations Using Positive Airway Pressure or Capnometry During ERCP

Launched by KARL LANDSTEINER UNIVERSITY OF HEALTH SCIENCES · Jul 3, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at ways to reduce breathing problems during a procedure called ERCP, which is used to examine and treat issues in the bile and pancreatic ducts. Sometimes, patients can experience low oxygen levels (called desaturation) during this procedure, especially because sedation (medicine to help you relax or sleep) is needed to complete it safely. The study will compare three different approaches to see which one helps keep oxygen levels more stable: using a special device to help with breathing (positive airway pressure), using extra monitoring to watch carbon dioxide levels in the breath (capnography), or the usual care with standard oxygen through a small tube in the nose.

Adults aged 18 to 99 who need an ERCP and will receive sedation by a nurse may be able to join, unless they have certain conditions like allergies to sedation medicine, a tracheostomy (a breathing tube in the neck), or need general anesthesia. During the procedure, participants will be closely monitored for their oxygen levels and other vital signs. The study will track how often low oxygen events happen and will follow patients for 30 days afterward to check for any late problems. This research hopes to find safer and more practical ways to prevent breathing difficulties during ERCP without needing full anesthesia or extra staff, making the procedure safer for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • undergoing an interventional (intent) ERCP procedure
• • 18-99 years
• • Male or female
• • Nurse-administered sedation
• Exclusion Criteria:
• • History of allergic reaction to Propofol
• • Tracheostomy
• • Procedure requiring intubation, general anesthesia, or anesthesiologist backup (acute exacerbation of obstructive lung disease, acute congestive heart failure, supra-glottic or sub-glottic tumor, septic shock, e.g.) according to the endoscopist in charge
• • Pregnant patients