Therapeutic Outcomes of Selective Serotonin Reuptake Inhibitors and Phosphodiesterase-5 Inhibitors Combination Therapy Versus Monotherapy

Launched by SOUTH VALLEY UNIVERSITY · Jul 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying treatments for premature ejaculation (PE), a common condition where a man ejaculates too quickly during sex, often within about one minute of penetration, which can cause distress and affect intimacy. The study will compare how well two types of medications work when taken alone versus when combined: selective serotonin reuptake inhibitors (SSRIs), which are often used to help with mood and can also delay ejaculation, and phosphodiesterase-5 inhibitors (PDE-5 inhibitors), commonly used for erectile dysfunction but thought to help with PE when used together with SSRIs.

Men between the ages of 18 and 60 who have been diagnosed with premature ejaculation according to specific medical guidelines may be eligible to join the study. Healthy men without PE might also participate as a comparison group. However, men with other sexual problems, heart issues, neurological or mental health conditions, or those currently taking medications that affect sexual function will not be eligible. Participants can expect to receive either one medication alone or both medications combined, and the study will look at how these treatments improve the time before ejaculation and overall satisfaction. This trial is not yet recruiting, so interested individuals should watch for updates on when they can join.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Patients with PE: Men aged 18-60 years with a diagnosis of PE according to the International Society for Sexual Medicine (ISSM) criteria.
• • Healthy controls: Men aged 18-60 years without a history of PE or other sexual dysfunctions.
• Exclusion Criteria:
• • Other sexual dysfunctions: Erectile dysfunction, delayed ejaculation, or other sexual disorders.
• • Cardiovascular disease: history of cardiovascular disease, hypertension, or stroke.
• • Neurological or psychiatric disorders: Conditions that may affect sexual function, such as depression, anxiety, or Parkinson's disease.
• • Medications affecting sexual function: Current use of medications that may impact sexual function, such as antidepressants or antipsychotics.