Constraint-induced Movement Therapy Versus Task-oriented Training On Upper Extremity Function Post-Botox Injection in Stroke Patients

Launched by CAIRO UNIVERSITY · Jun 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different types of therapy to help improve arm and hand movement in people who have had a stroke and received Botox injections to reduce muscle stiffness. The two therapies being compared are Constraint-Induced Movement Therapy, which encourages using the affected arm by limiting the use of the unaffected one, and Task-Oriented Training, which focuses on practicing specific daily activities. The goal is to see which therapy helps patients regain better function in their affected arm after Botox treatment.

People who might be eligible for this study are adults between 45 and 60 years old who have moderate stiffness and weakness on one side of their body from a recent stroke. They need to be able to sit steadily and have some movement in their affected hand and wrist. Therapy sessions would start a few days after the Botox injection and involve guided physical exercises. Those with severe joint problems or significant memory or thinking difficulties would not be able to join. This study has not started recruiting yet but aims to find the best way to support stroke recovery after Botox treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The study focuses on patients aged 45-60 years who have subacute spastic hemiplegia with occlusion of the middle cerebral artery and are able to maintain balance in sitting positions. Patients are diagnosed with the affected upper extremity being the dominant side. Physiotherapy sessions are initiated 3-7 days post-injection, and patients have pre-injection Modified Ashworth scores equal to 2 (moderate spasticity) in wrist or elbow flexors. Patients can actively extend joints at least 10° at metacarpophalangeal and interphalangeal joints and 20° at the wrist of the affected upper limb.
• Exclusion Criteria:
• • 1. Joint immobility in the upper limb due to contracture, bony deformity, or heterotopic ossification
• • 2. Significant cognitive deficits (Mini-Mental Status Examination score \<24).