UHF ECG in LBBB and Response to CRT Prediction

Launched by FACULTY HOSPITAL KRALOVSKE VINOHRADY · Jun 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help patients with a specific type of heart problem called Left Bundle Branch Block (LBBB), which affects how the heart’s electrical signals move and can make heart failure worse. The researchers want to see if a special type of heart test called an ultra-high-frequency ECG (UHF-ECG) can better identify patients who truly have LBBB compared to other similar heart conditions. They also want to find out if these patients respond better to a certain type of treatment called left bundle branch pacing (a way to help the heart beat more normally) compared to the standard treatment called biventricular pacing. Finally, the study will look at whether improvements in heart function after treatment relate to how well the heart’s timing improves.

People who might join this study are adults between about 65 and 74 years old who have heart failure caused by either blocked heart arteries or other heart muscle problems. To qualify, they need to have a weaker heart (with a measurement called ejection fraction of 40% or less), specific patterns on their heart test showing a wide QRS complex (which means the heart’s electrical signal takes longer than normal), and they must be scheduled for a therapy to help their heart beat better. Participants will undergo special heart studies before treatment and then receive one of the pacing therapies. It’s important to know that people with certain other heart problems, recent heart surgeries, or serious health issues won’t be able to join. If you or a loved one fits these criteria, this study could help improve how doctors identify and treat heart rhythm problems in heart failure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • HF due to ischemic or non-ischemic cardiomyopathy
• • known coronary angiography
• • NYHA II-IV
• • LVEF ≤40%
• • non-RBBB QRSd lasting \>130 ms (by automated measurement)
• • proximal LBBB proved by an invasive EP study or non-invasive dyssynchrony assessment in case such a method is confirmed to be non-inferior to an invasive EP study during the project
• Exclusion Criteria:
• • Age ˂18 years
• • heart failure from reversible causes
• • Moderate to severe aortic stenosis
• • pregnancy
• • active myocarditis
• • hypertrophic cardiomyopathy
• • cardiac valve surgery in the last three months
• • myocardial infarction, PCI, or CABG in the last three months
• • severe valvular disease requiring intervention
• • severe atherosclerotic disease of the aorta and/or femoral arteries
• • life expectancy ˂1 year
• • known medical condition or contraindication causing potential complications for EP study