A Pilot Study of 13^Carbon-based Deep Labeling of Bone Marrow Cells to Map Their Utilization of Extracellular Metabolites
Launched by MAYO CLINIC · Jun 30, 2025
Trial Information
Current as of July 14, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
PRIMARY OBJECTIVE:
I. Evaluate differences in the amount of extracellular uptake of glucose and amino acids (AAs) between pre-malignant clonal plasma cells (cPCs) and polyclonal plasma cells (pPCs).
OUTLINE: This is an observational study. Participants are assigned to 1 of 2 groups.
GROUP I: Patients undergo blood collection and bone marrow aspiration as part of their standard care and have their medical records reviewed on study.
GROUP II: Healthy volunteers undergo blood collection and bone marrow aspiration on study.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- * ALL PARTICIPANTS:
- • At least age 18 years or older
- • Able to provide informed consent
- * MGUS COHORT:
- • International Myeloma Working Group (IMWG) criteria for the diagnosis of non-IgM MGUS
- Exclusion Criteria:
- * ALL PARTICIPANTS:
- • Unable to provide consent
- • Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) \>1
- • Prior history of adverse events with conscious sedation
- • Ongoing use of immunosuppressive medications
- • All known pregnant and lactating women will be excluded
About Mayo Clinic
Mayo Clinic is a renowned nonprofit medical practice and research institution dedicated to providing comprehensive healthcare and advancing medical knowledge through innovative research and education. With a commitment to patient-centered care, Mayo Clinic conducts numerous clinical trials aimed at exploring new therapies and improving treatment outcomes across various disciplines. Leveraging a multidisciplinary approach, the institution collaborates with leading experts and cutting-edge technology to ensure rigorous scientific standards and ethical practices in all its research endeavors. Through its trials, Mayo Clinic seeks to translate breakthroughs in science into tangible benefits for patients, fostering advancements in medicine that enhance health and quality of life.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rochester, Minnesota, United States
Patients applied
Trial Officials
Wilson I. Gonsalves, MD
Principal Investigator
Mayo Clinic in Rochester
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported