Total Arterial vs. Mixed Grafting in Left Coronary CABG

Launched by SECOND HOSPITAL OF JILIN UNIVERSITY · Jul 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different ways to perform heart bypass surgery for people with blocked arteries in the heart. The surgery, called coronary artery bypass grafting (CABG), helps improve blood flow by creating new paths around blocked arteries. This study compares using only artery grafts (from the chest and arm arteries) versus the usual method that uses a mix of artery and vein grafts (from the chest artery and leg veins) to see which approach works better after one year. The main goal is to check how well the grafts stay open, which is important for the heart to get enough blood. The study will also look at any complications after surgery and long-term heart health.

Adults who have multiple blocked heart arteries and are scheduled for planned bypass surgery involving at least three vessels may be eligible to join. People must be able to give informed consent and should not have had recent heart attacks, strokes, or other serious health problems that could affect surgery. Participants will be randomly assigned to one of the two grafting methods and will be followed for at least a year, including imaging tests to check the grafts. This study aims to help doctors choose the best type of grafts to improve outcomes for patients needing bypass surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years
• • 2. Diagnosed with multivessel coronary artery disease
• • 3. Indicated for elective coronary artery bypass grafting (CABG) involving ≥3 coronary vessels
• • 4. Right coronary artery stenosis \>75%
• • 5. Able and willing to provide written informed consent
• Exclusion Criteria:
• • 1. Scheduled for concurrent cardiac procedures (e.g., valve surgery, congenital heart disease repair, aortic dissection surgery, atrial fibrillation ablation)
• • 2. Severe stenosis of left or right subclavian artery
• • 3. Unsuitable saphenous veins (e.g., bilateral varicosities)
• • 4. Unsuitable radial artery as assessed preoperatively
• • 5. History of intracranial hemorrhage or ischemic stroke within the past 14 days
• • 6. Severe hepatic or renal insufficiency
• • 7. Acute myocardial infarction within 72 hours prior to surgery
• • 8. History of prior CABG or other cardiac surgery