Investigation of the Effect of the MIND Diet on Disease Symptoms in Patients With MS

Launched by BETUL UNER · Jul 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether following the MIND diet—a way of eating designed to support brain health—can help people with Multiple Sclerosis (MS) feel less tired, think more clearly (reduce "brain fog"), and improve their overall quality of life compared to a traditional healthy diet common in Türkiye. The researchers want to see if this specific diet can make a positive difference in managing MS symptoms over a period of three months.

To join the study, participants need to be adults aged 18 to 65 who have had MS for at least three months, are regularly taking their MS medications without recent changes, and have a body weight within a normal range. They should not be pregnant, have other major health issues, or be on special diets or certain medications like antidepressants. Those who take part will follow either the MIND diet or the traditional healthy diet, attend weekly online meetings to check how well they are sticking to the diet, and visit the hospital for a health check-up after three months. This study aims to help better understand if diet changes could be a useful part of managing MS symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult MS patients between the ages of 18-65 diagnosed according to the 2017 McDonald criteria
• • Having been diagnosed with MS at least three months ago; patients are called for routine check-ups in the first and third months after starting treatment, as liver function tests and/or hemogram values may be impaired due to the treatment they started when they are newly diagnosed with MS. For this reason, it was planned to include patients whose check-ups were completed and no unexpected changes were observed in the blood parameters table due to the medication.
• • No DMT change in the last 6 months
• • Patients who use their medications regularly
• • Not using nutritional support or supplements
• • Patients with an EDSS score of ≤6
• • Patients with a body mass index (BMI) between 18.5-24.9 kg/m2
• Exclusion Criteria:
• • MS patients who are pregnant or lactating
• • Having another chronic metabolic disease and/or having had surgery in the last 3 months
• • MS patients with limb deficiency
• • MS patients on a special diet
• • Patients using antidepressants and/or mood stabilizers
• • Having had an attack and/or receiving steroid treatment in the last month