Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD Registry)

Launched by BEIJING TIANTAN HOSPITAL · Jul 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new surgical treatment called deep cervical lymphatic venous anastomosis (DC-LVA) to see if it can help improve symptoms in people with Alzheimer’s disease. The main goal is to find out if this surgery can reduce memory and thinking problems, measured by a common test called the clinical dementia rating-sum of boxes (CDR-SB), one year after the procedure. The study will observe patients in real-life medical settings to better understand how safe and effective the surgery is.

People who might be eligible for this study are adults diagnosed with Alzheimer’s disease, aged 18 or older, who have already received the DC-LVA surgery. Participants need to have a stable caregiver who can help them throughout the study because regular follow-up visits are required. People with severe difficulties in movement, speech, vision, hearing, or consciousness that would make it hard to complete memory tests won’t be eligible. If you or a loved one meet these criteria and have had this surgery, this study may help provide important information about this treatment’s benefits and safety over time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years, male or famale.
• • 2. Diagnosed with AD according to the NIA-AA criteria.
• • 3. Patients who have received DC-LVA treatment;
• • 4. Signed informed consent (by the subject or their relative, and caregiver)
• Exclusion Criteria:
• • 1. Severe neurological deficits in limb movement, language, vision, hearing, or consciousness, or any condition that the investigator determines may prevent the completion of cognitive function assessments.
• • 2. The subject lacks a stable and reliable caregiver to accompany with them during entire study follow-up visits.