Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty
Launched by STATE BUDGETARY HEALTHCARE INSTITUTION, NATIONAL MEDICAL SURGICAL CENTER N.A. N.I. PIROGOV, MINISTRY OF HEALTH OF RUSSIA · Jul 9, 2025
Trial Information
Current as of July 22, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether adding a medication called ketamine to the usual pain relief methods can help people feel less pain after knee replacement surgery. The researchers want to see if ketamine can reduce the need for opioid pain medicines (which can have side effects) and still keep pain under control without causing extra problems like nausea or unusual reactions.
Adults between 18 and 90 years old who have had knee replacement surgery may be able to join the study, as long as they don’t have certain types of anesthesia or nerve blocks during or after surgery and aren’t allergic to ketamine or similar drugs. Participants will be randomly placed into two groups: one will receive the standard pain treatments, and the other will get the same treatments plus a continuous ketamine infusion that they can control themselves through a device. For the first 24 hours after surgery, their pain levels and any side effects will be closely monitored. This study aims to find better ways to manage pain after knee surgery, potentially helping patients recover more comfortably.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age greater than 18 years and less than 90 years.
- • Patients who have undergone knee arthroplasty.
- • The patient has read the information sheet and signed the informed consent form.
- Exclusion Criteria:
- • Spinal anesthesia performed intraoperatively.
- • Epidural analgesia administered postoperatively.
- • Perioperative blockade of the sciatic nerve, genicular nerve, or lumbar plexus.
- • Allergy to ketamine or non-steroidal anti-inflammatory drugs.
- • Contraindications to ketamine as specified in the product instructions.
- • Time from the end of surgery to study enrollment exceeds 24 hours.
- • Ineffectiveness of analgesia as provided by the study protocol.
About State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry Of Health Of Russia
The National Medical Surgical Center named after N.I. Pirogov, a state budgetary healthcare institution under the Ministry of Health of Russia, is a leading clinical trial sponsor dedicated to advancing medical research and improving patient outcomes. With a strong emphasis on innovative surgical techniques and comprehensive healthcare solutions, the center operates at the forefront of clinical trials, facilitating the development and evaluation of new therapies and medical devices. Leveraging its state-of-the-art facilities and a team of expert clinicians, the institution fosters collaboration with national and international research entities to enhance the efficacy and safety of medical interventions, ultimately contributing to the advancement of public health in Russia and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Moscow, , Russian Federation
Patients applied
Trial Officials
Boris Teplykh, MD
Study Director
Pirogov National Medical and Surgical Center
Ivan Shcheparev, MD, PhD
Principal Investigator
Pirogov National Medical and Surgical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported