Effect of Different Root Canal Sealers on Oxidative Stress Markers

Launched by BENGI GÜLGÜ · Jul 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different materials used in root canal treatments affect certain stress markers found in saliva, called oxidative stress markers, in people with a chronic infection at the tip of a tooth root (chronic apical periodontitis). The researchers want to see if these stress markers change after treatment and whether the type of root canal sealer used—either a bioceramic-based or an epoxy resin-based paste—makes a difference in these changes. This could help better understand how different treatments impact healing and overall oral health.

People who might be eligible for this study are adults between 18 and 45 years old who are generally healthy, do not smoke or drink alcohol, and have a specific tooth infection in a multi-rooted tooth that is less than 2 cm in size. Participants will have their saliva collected twice: once during the root canal treatment and again 30 days later to measure changes in stress markers. Before joining, participants will receive all the necessary information about the procedure and must agree voluntarily by signing a consent form. The study excludes those with other health issues, recent antibiotic use, poor oral hygiene, or complications with the tooth in question. This research aims to provide clearer information on how different root canal sealers affect the body’s response to treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Systemically healthy, ASA1 patients,
• • Phase 1 periodontal treatment was performed,
• • Diagnosed with chronic apical periodontitis in a single tooth with 2 or more roots in the mouth,
• • The lesion measured \<2 cm on radiographic evaluation,
• • The vitality of the tooth was checked by EPT (Ai-Pex, Woodpecker, China) and Cold test (Cerkamed, Poland) and confirmed to be devitalised,
• • Socioculturally able to participate in the treatment,
• • Individuals who did not smoke or drink alcohol
• Exclusion Criteria:
• • Patients who have used antibiotics in the last three months and analgesics in the last two weeks
• • Patients who smoke and/or abuse alcohol
• • Patients younger than 18 years or older than 45 years,
• • Patients with controlled or uncontrolled systemic disease and life-threatening conditions (ASA 2,3,4,5,6)
• • Pregnant or lactating women,
• • Patients with poor oral hygiene,
• • Patients who had head and neck radiotherapy,
• • With obesity,
• • Active periodontal disease,
• • Periodontal pocket depth over 3mm,
• • There is enough loss of material in the relevant tooth to prevent adequate isolation or to require post placement,
• • Clinical examination of the relevant tooth showing symptoms in percussion-palpation,
• • Radiographically, the lesion is seen in relation to anatomical formations such as the mandibular canal and maxillary sinus,
• • Patients who required prophylactic antibiotic use before invasive dental procedures were excluded from the study.
• • Patients who did not attend the follow-up appointment and patients who experienced complications during expansion (instrument seperation, perforation, etc.) were excluded from the study.