Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study

Launched by ASSIUT UNIVERSITY · Jul 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different treatments for melasma, a common skin condition that causes dark patches on the face. The study will compare how well a 1% resveratrol gel—a natural substance found in some plants—works against a chemical peel using 20% trichloroacetic acid (TCA), which is a stronger, doctor-applied treatment. The goal is to see which treatment is safer and more effective at reducing the dark spots.

People who might be eligible to join are adults between 18 and 50 years old who have melasma on both sides of their face and have medium to darker skin tones (skin types III, IV, or V). Pregnant or breastfeeding women, those using certain hormone treatments, or people with certain skin conditions or history of skin problems won’t be able to join. Participants can expect to have one side of their face treated with resveratrol gel and the other side with the chemical peel so the researchers can directly compare results. This study is not yet recruiting, but it aims to help find better, safer ways to treat melasma in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Age: 18-50 years old.
• • Pattern of melasma: Bilateral symmetrical facial melasma of any pattern.
• • Fitzpatrick skin phototypes: Types III, IV and V.
• Exclusion Criteria:
• • Pregnancy and lactation.
• • Patients taking oral contraceptive pills, hormonal replacement therapy or treatment for chronic illness at the time of the study or during the past 6 months.
• • Coexistence of diseases associated with hyperpigmentation such as Addison disease.
• • History of Scarring and keloid tendency
• • Active skin infections as active HSV.
• • Previous history of post- inflammatory hyperpigmentation.