Presepsin Diagnostic Performance in Severe Burn Sepsis

Launched by DOHERN KYM · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a blood test called presepsin to see how well it can detect sepsis early in adults with severe burns. Sepsis is a serious, life-threatening reaction to infection, and it’s especially important to find it quickly in burn patients because their bodies are more vulnerable. The study will include about 270 adults who have burns covering at least 20% of their body and who are suspected of having sepsis. Researchers will compare presepsin levels with other blood tests and clinical signs to check how accurate presepsin is at diagnosing sepsis.

If you join the study, you’ll have blood samples taken at specific times while you’re in the hospital’s burn unit. These tests will help doctors see if presepsin can spot sepsis sooner than other methods. To be eligible, participants must be adults admitted with serious burns and have a possible infection that needs testing. People who can’t have blood drawn due to emergency surgery, those with certain immune system problems, pregnant women, or those unable to consent won’t be able to join. The goal is to improve how quickly sepsis is found and treated in burn patients, which could lead to better recovery and outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged ≥ 18 years admitted to Hangang Sacred Heart Hospital Burn ICU with total body surface area (TBSA) ≥ 20 %
• • Clinical suspicion of sepsis prompting blood culture and biomarker sampling
• • Ability to understand the study and provide written informed consent (or via legally authorized representative)
• Exclusion Criteria:
• • Inability to undergo research blood draw due to emergent surgery or major trauma at sampling time
• • Chronic immunosuppressive conditions (e.g., long-term high-dose steroids, organ transplant, congenital immunodeficiency)
• • Pregnant women or those with significant psychiatric conditions precluding consent
• • Any other medical or safety concerns deemed inappropriate by the investigator