Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes

Launched by FRANCESC COLOM, PSYD, PHD · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a special online program designed to help women with mild to moderate depression. The program combines online lessons about depression and women’s health with personal video sessions with a psychologist. Over 10 weeks, participants will learn about topics like mood changes related to the menstrual cycle, body image, stress, caregiving, and how gender-related experiences can affect mental health. The study aims to see if this personalized approach helps improve depression more than just watching short educational videos, while still continuing any usual treatments.

Women between 18 and 45 years old, who have mild to moderate symptoms of depression and can speak Spanish, may be eligible to join. Participants will need internet access and basic skills with digital devices like a smartphone or computer. The study will also collect biological samples to understand how hormones and metabolism might affect how well the program works. This research hopes to make mental health care more accessible and tailored to women’s needs in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women
• • Age between 18 and 45 years (inclusive)
• • Mild to moderate depressive symptoms, defined by a score of 17 to 23 on the 17-item Hamilton Depression Rating Scale (HDRS-17)
• • Fluent in Spanish
• • Access to the internet and the ability to use digital devices (e.g., smartphone, tablet, or computer)
• Exclusion Criteria:
• • Currently receiving psychological therapy
• • Participation in any other interventional clinical trial for depression within the past 3 months
• • Pregnant or planning to become pregnant during the study period
• • Cognitive impairment that may interfere with informed consent or study participation
• • Presence of psychotic symptoms, active suicidal ideation, or current substance abuse disorder