Tafenoquine and DHA-piperaquine (TADORE- Plus)

Launched by MENZIES SCHOOL OF HEALTH RESEARCH · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how two malaria medicines—tafenoquine and DHA-piperaquine—work when taken together to treat vivax malaria, a type of malaria caused by a specific parasite. The main goal is to find out if these medicines interact in a way that affects how well they work or how safe they are. To do this, some participants will receive the full treatment right away, while others will get part of the treatment later, allowing researchers to compare the results over six months.

Adults aged 18 and older who have vivax malaria confirmed by a blood test, normal levels of an enzyme called G6PD (which helps prevent certain side effects), and a fever or recent history of fever may be eligible to join. Participants must also have a certain level of hemoglobin (a protein in red blood cells) and be willing to stay in the study area for follow-up visits over six months. People with severe malaria symptoms, pregnant or breastfeeding women, those taking certain other medicines, or with a history of psychiatric problems cannot join. If you participate, you can expect to be closely monitored for your health and response to the medicines to help researchers understand the best way to use these treatments safely and effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • P. vivax peripheral parasitaemia (mono-infection)
• • G6PD normal status (G6PD activity ≥70% of the adjusted male median
• • as determined by the Standard G6PD (SD Biosensor, ROK))
• • Fever (temperature ≥37.5⁰C) or history of fever in the preceding 48 hours
• • Age ≥18 years
• • Haemoglobin at presentation ≥8g/dl
• • Written informed consent.
• • Living in the study area and willing to be followed for six months
• Exclusion Criteria:
• • Danger signs or symptoms of severe malaria
• • Pregnant or lactating females
• • Regular use of drugs with haemolytic potential
• • Known hypersensitivity to any of the study drugs
• • History of any psychiatric disorder