Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients

Launched by CEREN DERYA GÜLTEKIN · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different types of breathing exercises, called inspiratory muscle training, can help people who are undergoing a hematopoietic stem cell transplant—a procedure often used to treat blood diseases. After this transplant, patients can have trouble breathing, feel very tired, and experience a lower quality of life. The study aims to see which type of breathing exercise is best at improving breathing strength, endurance, exercise ability, muscle function, fatigue, and overall well-being during the transplant process.

Adults between 18 and 65 years old who are preparing for this transplant and are physically able to walk and follow instructions may be eligible to join. People with certain health problems like asthma, lung diseases, or conditions that make exercise unsafe won’t be included. Participants will be randomly placed into one of three groups: one doing standard breathing exercises, one doing breathing exercises combined with special functional movements, and a control group. Everyone in the exercise groups will do breathing training for about 30 minutes twice a day on weekdays, with some doing extra exercises three times a week. A physiotherapist will supervise all sessions. The study will check participants’ breathing, muscle strength, fatigue, mood, and quality of life before, during, and after the transplant. This is the first study to look closely at how these breathing exercises affect muscle function and overall health in this patient group, which could help improve care for future transplant patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Planned haematopoietic stem cell transplantation in the adult bone marrow transplant unit
• • Between the ages of 18-65
• • Under standard medical treatment, including immunosuppressives, antibiotics and other medications
• • Ability to walk, co-operate and be clinically stable
• • No history of orthopaedic, neurological, cardiac disorders
• Exclusion Criteria:
• • Cognitive disorders
• • Have orthopaedic or neurological diseases that may affect the assessment of physical fitness tests
• • Having comorbidities such as asthma, COPD
• • Conditions in which exercise training is contraindicated, such as acute bleeding, haemoglobin value \<5 g/dl, platelet count ≤10000 mm3, high fever (body temperature \>38◦C), severe pain, confusion, dizziness, nausea and vomiting
• • Patients with pneumonia or any acute infection
• • -≥ 3 consecutive sessions of interruption of the exercise group subjects' attendance to the training protocol
• • Loss of willingness to participate in the research during the research process
• • Development of clinical haemodynamic instability in patients