Brachial-radial Pressure Gradient Phenomenon in Critically Ill Patients Treated With Vasoactive Agents

Launched by JAGIELLONIAN UNIVERSITY · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how blood pressure readings may differ between two arteries in the arm (the brachial artery near the upper arm and the radial artery near the wrist) in very sick patients who are being treated with medicines called vasoactive agents. These medicines help support blood pressure and circulation in people experiencing shock or circulatory failure. The researchers want to find out how often there is a difference in pressure readings between these two arteries, whether this difference is bigger when higher doses of these medicines are used, and if the difference is linked to poorer blood flow to the body’s tissues.

Adults over 18 who are in the intensive care unit (ICU), have already received initial treatment for their condition, and are receiving continuous blood pressure monitoring through a small tube placed in their wrist artery may be eligible to take part. Participants will be observed while on vasoactive medicines, and measurements will be taken to compare blood pressure between the two arteries. The study does not involve additional treatments or interventions beyond these measurements. People who are pregnant, require certain types of heart support machines, or cannot have the blood pressure cuff properly placed on their arm will not be able to join. This study aims to help doctors better understand blood pressure monitoring in critically ill patients to improve care.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • adult (\>18 years) patients admitted to the ICU
• • must be after initial resuscitation
• • invasive blood pressure monitoring in the radial artery
• • need for vasoactive drug therapy
• Exclusion Criteria:
• • pregnancy
• • pressure transduction across invasive blood pressure circuit deemed to be inadequate
• • mechanical circulatory support
• • inability to match non-invasive cuff size to the patient's arm
• • need for any hemodynamic intervention during performing study's measurements
• • patient's decline to have the measurements done