Endoscopic Ultrasound-guided Measurement of Portal Vein Pressure Gradient

Launched by ZHEJIANG UNIVERSITY · Jul 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to measure pressure in a major vein of the liver using a special ultrasound technique called EUS-PPG. This is important for people with liver cirrhosis (scarring of the liver) and blood clots in the liver’s main vein, conditions that can cause high pressure in the liver and lead to serious problems. The usual test for measuring this pressure isn’t always reliable for these patients, so this study wants to see if the new method is safe and accurate by comparing it to the standard test.

Adults with liver cirrhosis who meet certain health criteria—like having a good blood clotting status and platelet count—may be eligible to join. People with infections, kidney problems, or other serious conditions would not qualify. Participants will undergo both the new ultrasound-guided pressure measurement and the standard test while under anesthesia, lying on their left side. If bleeding veins are found during the procedure, doctors can treat them right away, which could mean fewer hospital visits and lower costs. The study will take place from 2025 to 2027 at Zhejiang University, and it aims to improve diagnosis and treatment for people with these liver conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years old
• • History of liver cirrhosis
• • INR \< 1.5
• • Platelet count \> 50 × 10⁹/L
• • Patients agreed to HVPG and EUS-PPG measurements
• Exclusion Criteria:
• • Patients with ascites
• • Patients with renal insufficiency
• • Patients with active infection
• • Patients with hepatic encephalopathy
• • Critically ill patients
• • Pregnant patients
• • Patients with immunodeficiency diseases (such as systemic lupus erythematosus)
• • Patients with mental illness
• • Patients with malignant tumors
• • Patients who refused to undergo HVPG and EUS-PPG measurements