Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy

Launched by TANTA UNIVERSITY · Jul 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different types of anesthesia affect brain pressure and oxygen levels during a laparoscopic hysterectomy, which is a minimally invasive surgery to remove the uterus. Researchers are comparing three anesthesia methods: sevoflurane alone, sevoflurane combined with a pain-relieving medicine called lidocaine given through an IV, and a method called propofol total intravenous anesthesia (TIVA). The goal is to see which approach is best at keeping the brain safe by monitoring pressure inside the head and oxygen supply using non-invasive tests.

Women between 18 and 65 years old who are generally healthy, with a body weight within a certain range, and scheduled for this type of surgery may be eligible to join. Participants can expect to receive one of the anesthesia methods during their operation, and the medical team will carefully monitor their brain pressure and oxygen levels without any painful procedures. People with certain eye conditions, serious health problems, or allergies to the study medications won’t be able to participate. This study is currently recruiting patients who meet these criteria.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age from 18 to 65 years.
• • American Society of Anesthesiologists (ASA) physical status I and Ⅱ.
• • Body mass index (BMI) ≤35.
• • Females scheduled for laparoscopic hysterectomy.
• Exclusion Criteria:
• • Patients' refusal to participate in the study.
• • Hypersensitivity and allergy to drugs of the study.
• • Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery
• • Any central nervous system or cardiovascular disease, severe hepatic or renal impairment
• • Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery
• • If peak inspiratory pressure (PIP) exceeds 35.