Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis

Launched by HOSPITAL ISRAELITA ALBERT EINSTEIN · Jul 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how children with meningitis—a serious infection of the lining around the brain and spinal cord—are treated and how they recover both during their hospital stay and after they go home. The study will take place in about 20 hospitals across Brazil and will collect information to better understand current treatment methods and long-term outcomes. This will help doctors improve care for children with different types of meningitis, including bacterial, viral, and fungal infections.

Children under 18 who have a fever along with symptoms like severe headache, vomiting, confusion, sensitivity to light, seizures, stiff neck, or a sudden rash may be eligible to join. For babies under two years old, signs such as irritability, constant crying, sleepiness, or a soft spot on the head that looks swollen are also considered. Families who agree to participate will have their child’s health closely followed during the hospital stay and after discharge to see how well treatments are working. The study is not yet enrolling participants but aims to gather important real-world information to help improve care for children with meningitis in Brazil.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Fever (axillary temperature ≥37.8°C) followed by two or more of the following symptoms\*: severe headache, vomiting, altered consciousness (confusion, drowsiness, or irritability), photophobia (increased sensitivity to light), presence of seizures OR
• • Fever accompanied by at least one meningeal irritation sign, such as neck stiffness, Kernig's sign, or Brudzinski's sign OR
• • Sudden onset of fever and appearance of petechial skin rash or hemorrhagic suffusions
• • In children younger than two years, in addition to the presentations listed above, consider fever with any of the following: irritability, persistent crying, somnolence, or bulging fontanelle.
• Exclusion Criteria:
• • Refusal to provide consent for study participation