A Multicentre Clinical Study

Launched by ZHONGDA HOSPITAL · Jul 11, 2025

Keywords

ClinConnect Summary

This clinical study is looking at new ways to help diagnose and understand depression using special brain imaging and eye-tracking technology. Researchers will use a tool called near-infrared spectroscopy (fNIRS) to observe how oxygen levels in the brain change during thinking tasks, and eye tracking to see how eye movements differ in people with depression compared to those without it. The goal is to find reliable markers that can help doctors diagnose depression more objectively and predict how well patients might respond to treatment after two weeks.

People aged 18 to 60 who have been diagnosed with depression according to standard guidelines, have had symptoms for at least two weeks, and meet certain severity criteria may be eligible to join. Participants should be right-handed and should not have other serious health problems or mental illnesses. During the study, participants will undergo brain scans and eye movement tests before starting treatment, and some tests may be repeated after two weeks to see if changes in the brain and eyes relate to improvement in depression symptoms. This study aims to give doctors better tools to diagnose depression and tailor treatments more effectively in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18-60 years old; ② Right-handed; ③ Meet the DSM-5 diagnostic criteria for depression; ④ The current course of disease (last onset) is at least 2 weeks; ⑤HAMD-17 score ≥17 points; ⑥ No electroconvulsive therapy was received in the first six months.
• Exclusion Criteria:
• • A combination of another mental illness; A history of alcohol/drug dependence or smoking \> 10 cigarettes/day; ③ Serious physical diseases of the heart, liver, kidney, brain and hematopoietic system, central nervous system infection, head injury, epilepsy, multiple sclerosis, toxic metabolic diseases, Parkinson's disease or intracranial tumors; ④ Family history of hereditary diseases; ⑤Endocrine system diseases such as diabetes, hyperthyroidism or hypothyroidism; ⑥ Pregnant, lactating women or photosensitivities.