Progressive Inhibition of Neuromuscular Structure and Neural Tissue Mobilization.

Launched by RIPHAH INTERNATIONAL UNIVERSITY · Jul 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two special therapy techniques to help people who have lumbar radiculopathy, a condition where nerve pain from the lower back spreads down the leg and feels sharp, burning, or electric. The study is looking at whether these therapies—called neural mobilization and Progressive Inhibition of Neuromuscular Structures (PINS)—can reduce pain, improve movement, and lower disability in people with this condition. Neural mobilization involves gently moving the nerve to relieve pain, while PINS uses targeted pressure on muscles and nerves to ease muscle tension and discomfort.

People who might be eligible for this study are adults aged 18 to 40 who have had chronic lumbar radiculopathy for at least three months, specifically affecting one side of the lower back (at the L4-L5 or L5-S1 levels). To join, participants should experience leg pain triggered by certain simple physical tests and must not have more severe or complicated back problems like widespread nerve damage, past spinal surgery, or other serious health concerns. If you join the trial, you can expect to receive these specialized therapy treatments aimed at easing your symptoms and improving your daily function. The study isn’t recruiting yet, but it aims to find better ways to help people with this type of nerve pain.

Gender

ALL

Eligibility criteria

• • INCLUSION CRITERIA
• • Age group between 18 and 40 years(.
• • Both gender male and female.
• • Participants diagnosed as having a chronic (lasting three months or longer) lumbar radiculopathy.
• • Diagnosed patient of having radiculopathy at level of L4-L5 and L5-S1 lesion (unilateral radiculopathy).
• • Radiating pain evoked by specific clinical tests, including slump and straight leg raise.
• Exclusion Criteria:
• • Individuals having bilateral lumbar radiculopathy.
• • Spondylolysis/spondylolisthesis
• • Mechanical systemic low back pain or neoplasmic and infectious processes.
• • Participants with severe nerve root compression (non-ambulant/wheelchair-bound).
• • Any sign or symptom of dementia or other cognitive impairments.
• • Diagnosis of claudication, previous spinal surgery, pregnancy and presence of any of the spinal red flags.