A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants

Launched by BRISTOL-MYERS SQUIBB · Jul 11, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how new versions of two experimental medicines, called KarX and KarT, work in the body compared to earlier versions named KarXT and KarX-EC. The study will test single doses of these medicines to see how they behave, and it will also explore how eating food affects the way the body handles these medicines when taken multiple times. This research is being done with healthy adult volunteers to better understand the medicines before they are tested in patients with health conditions.

To take part, volunteers need to be adults with a body mass index (BMI) between 18.0 and 32.0, which is a way to measure if someone is in a healthy weight range. The study is open to all genders, and other health criteria will be checked to make sure participants are a good fit. If you join, you can expect to receive the study medicines under controlled conditions, and researchers will monitor how your body processes them, including how food might change this. This early-phase study helps gather important information to guide future research and ensure the medicines are safe and effective.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI between 18.0 kg/m2 to 32.0 kg/m2, inclusive, at screening.
• • Other protocol-defined Inclusion/Exclusion criteria apply.