Clinical Performance and Remineralization Potential of Self- Assembling Peptide P11-4 Containing Fluoride Versus Er, Cr: YSGG Laser Treatment and Micro Tensile Bond Strength of Giomer Restoration in Carious Lesions

Launched by AL-AZHAR UNIVERSITY · Jul 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help repair teeth that have early damage from cavities, specifically the hard layer beneath the enamel called dentin. Researchers are comparing a special treatment that uses a self-assembling peptide (a small protein) combined with fluoride, which may help rebuild the tooth, to a laser treatment called Er, Cr: YSGG. The goal is to see which method better helps the tooth heal and become stronger over time.

Adults between 20 and 40 years old who have at least one back tooth with a moderate cavity that needs treatment might be eligible to join. Participants should be generally healthy, have good oral hygiene, and be willing to take part in the study. People with serious health issues, advanced tooth infections, allergies to the treatment, or poor gum health around the affected tooth won’t qualify. If you join, your tooth will be treated with either the peptide and fluoride or the laser, and the researchers will monitor how well your tooth repairs itself over one year using different tests done both in the mouth and in the lab. This study is not yet recruiting, but it aims to find better ways to protect and restore teeth affected by cavities.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • o Patients aged (20 - 40) years.
• • Presence of at least one posterior permanent molar with an occlusal carious lesion classified as ICDAS code 3 or 4 requiring operative treatment.
• • Good general and oral health.
• • Willingness to participate and provide informed consent.
• Exclusion Criteria:
• • o Patients with systemic conditions affecting oral health or healing.
• • Teeth with pulp involvement or periapical pathology.
• • Allergy to study materials.
• • Poor oral hygiene or periodontal disease in the target tooth region.