Impact of Early, Personalized Nutritional Management on 1-month Mortality After Acute Stroke

Launched by UNIVERSITY HOSPITAL, ANGERS · Jul 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether providing early, personalized nutrition support can help reduce the risk of death within one month after having a stroke. When someone has a stroke, they often have trouble eating enough, which can affect recovery. In this study, patients in the treatment group will be seen by a dietician within two days of their stroke. The dietician will check for any swallowing problems and work to make sure the patient gets the right amount of nutrition, either by adjusting their regular meals or, if needed, using feeding tubes or other methods. Their food intake will be closely monitored and adjusted during the first week after the stroke to meet their individual needs.

People who are 18 years or older, have had a recent stroke (within the last two days), and have a moderate to severe stroke (based on a standard stroke severity score) may be eligible. Participants need to be hospitalized for at least five days in certain specialized units and able to give consent themselves or have a family member consent for them. If accepted into the study, patients can expect regular nutrition assessments and support during their hospital stay. The study will also follow up by phone after 30 days to check on outcomes, and there will be an assessment of quality of life three months after the stroke. The goal is to see if this personalized nutrition approach can help improve survival and recovery after a stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria :
• • Patients ≥ 18 years of age
• • With an acute, ischaemic or haemorrhagic outpatient or inpatient stroke
• • NIHSS score ≥ 5
• • Hospitalised in a neurology department, or Neuro Vascular Unit (NVU), or in a department where beds are dedicated to receiving post-stroke patients
• • Stroke less than 2 days old
• • Anticipated length of hospital stay in a participating centre ≥ 5 days
• • Patient affiliated to or benefiting from a social security scheme
• • Patient or close relative having given written consent to participate in the study or patient included under the emergency procedure in the absence of contactable relatives
• Exclusion Criteria:
• • Patients treated with nutritional therapy at the time of admission (history of bariatric surgery or gastrectomy, malabsorptive pathologies such as short bowel, extensive intestinal resections, etc.).
• • In a palliative situation where life expectancy is \< 3 months
• • Patient taking part in another study with an impact on mortality or nutrition
• • Previous inclusion in the trial
• • Pregnant, breast-feeding or parturient woman
• • Patient unable to follow the protocol for any reason
• • Patient deprived of liberty by judicial or administrative decision
• • Patient under compulsory psychiatric care
• • Person under legal protection
• • Poor understanding of the French language