The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery

Launched by NANJING FIRST HOSPITAL, NANJING MEDICAL UNIVERSITY · Jul 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether a special pain relief medicine called bupivacaine liposome, given before surgery, can help reduce pain and lower the chance of confusion (called delirium) after hip fracture surgery in older adults. The goal is to find better ways to manage pain around the time of surgery, so patients recover more comfortably and with fewer complications.

The study is for people aged 65 and older who have a hip fracture and are planning to have surgery to fix it. To join, patients need to be generally healthy enough for surgery (based on a standard health rating system) and must agree to participate, or have a family member agree for them. People with certain conditions, like recent strokes, ongoing mental health issues, or allergies to the pain medicine, would not be eligible. Participants will receive the special pain relief before surgery, and researchers will monitor their pain levels and check if they experience any confusion after the operation. This trial is not yet recruiting patients but aims to improve recovery for older adults having hip surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with hip fractures scheduled for surgical treatment (including femoral neck fractures, intertrochanteric fractures, and fractures more than 5 cm below the lesser trochanter of the femur).
• • Age ≥65 years.
• • American Society of Anesthesiologists (ASA) grade I - III.
• • The patient or family member signed the informed consent form
• Exclusion Criteria:
• • Compound injuries (such as combined fractures of the head, chest, pelvis, or limbs).
• • Have a clear history of mental illness or are taking psychotropic drugs.
• • Preoperative delirium or the use of delirium-related medications (such as olanzapine).
• • A history of acute cerebrovascular disease (cerebral infarction or cerebral hemorrhage) within 6 months.
• • Patients requiring sedation or postoperative coma due to the condition.
• • Allergy to amide local anesthetics.
• • Severe arrhythmia or liver or kidney dysfunction