The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing

Launched by LARISSA UNIVERSITY HOSPITAL · Jul 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different ways of delivering high flow oxygen through the nose to people who have recovered from lung diseases and are currently stable. The goal is to see if an “asymmetrical” nasal high flow device helps reduce the effort it takes to breathe compared to a “symmetrical” device. Simply put, researchers want to find out which device makes breathing easier for these patients.

People aged 18 and older who do not have any signs of ongoing breathing problems and have good oxygen levels may be eligible to join. During the study, participants will try both types of nasal oxygen devices for about 15 minutes each, in a random order. While they use these devices, doctors will monitor their breathing effort and lung function using safe, non-invasive tests. This study is important because it may help improve breathing support for people recovering from lung conditions, making it easier and more comfortable for them to breathe.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. age ≥18 years old
• • 2. absence of symptoms and signs of respiratory failure (SpO2\>95% at FiΟ2 0.21)
• Exclusion Criteria:
• • 1. pregnancy
• • 2. SpO2\<94% at FiΟ2 0.21
• • 3. neuromuscular disease
• • 4. contraindications to esophageal pressure monitoring (e.g., uncontrolled coagulopathy, esophageal disease, nasal trauma, allergy to local lidocaine)