The Intensive Nutritional Support in Esophageal Cancer Undergoing Neoadjuvant Therapy

Launched by SICHUAN UNIVERSITY · Jul 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different types of nutritional support might help people with esophageal cancer who are receiving treatment before surgery (called neoadjuvant therapy). The goal is to see if giving extra, intensive nutrition helps improve patients’ nutritional health, quality of life, and their ability to have surgery compared to standard nutrition care.

People who may join this study are adults with a specific stage of esophageal cancer that can be treated with surgery after initial therapy. They must have some nutritional risk, meaning they may not be getting enough nutrients, and be well enough to participate based on their overall health. If eligible, participants will be randomly assigned to receive either usual nutrition support or more intensive nutritional care during their treatment. The study will then look at how these different approaches affect their health, nutrition, and chances of successful surgery. The trial is not yet recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Esophageal cancer；
• • 2. Patients were staged as cT1b-cT2N+M0 or cT3-cT4a, any N, M0. Based on the location of the tumor and clinical staging, they were defined as locally advanced resectable esophageal cancer；
• • 3. Patients planned for neoadjuvant therapy, with radical surgical resection intended after neoadjuvant treatment；
• • 4. Normal gastrointestinal function；
• • 5. PG-SGA score \>3;
• • 6. Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤2分.
• Exclusion Criteria:
• • 1. Other tumors, including pancreatic cancer, liver cancer and other solid digestive tract tumors, colon cancer, rectal cancer and other tubular lower digestive tract tumors;
• • 2. Have serious heart, lung and brain diseases;
• • 3. Patients with unstable vital signs and multiple organ failure;
• • 4. The patient has poor cognitive ability and is unable to answer questions or fill out questionnaires;
• • 5. Eastern Cooperative Oncology Group score \>2;
• • 6. The investigator believes that the subjects have a history of other serious systemic diseases or are not suitable for participating in this clinical study for other reasons