Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · Jul 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different ways to help people breathe after they are taken off a breathing machine (ventilator) in the hospital. The trial is looking at patients who are considered high risk for breathing problems once the ventilator is removed. Doctors usually use a method called Non-Invasive Ventilation (NIV), which means helping patients breathe using a mask without putting a tube down their throat. In this study, some patients will continue with the usual NIV care, while others will try a different method called Biphasic Cuirass Ventilation (BCV), which uses a special device placed on the chest to assist breathing.

To be part of this study, patients need to be adults between 18 and 80 years old who are in the intensive care unit and expected to need breathing support after coming off the ventilator. People who are pregnant, have certain chest problems, very high body weight, or specific muscle or nerve conditions won’t be able to join. If you take part, you will be randomly assigned to one of the two breathing support methods, and doctors will closely monitor how well each method works in helping you breathe after extubation. This study is not yet recruiting patients but aims to find out which breathing support method might be better for patients at high risk of breathing difficulties after ventilator use.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • High risk extubation patients in the Medical Intensive care units who are being thought to be placed on non invasive ventilator post extubation.
• Exclusion Criteria:
• • Age \<18 or \>80
• • Pregnant
• • Inmate/Prisoner
• • Chest wall defects
• • BMI \>50
• • History of Diaphragmatic paralysis
• • History of Neuromuscular disease
• • Contraindication to study device (open chest wound, flail chest, complex thoracic surgeries in the past)