Role of Musculoskeletal Ultrasound for Early Detection of Synovitis in SLE Patient and Its Correlation With Disease Activity and Neutrophil-to-C3 Ratio.

Launched by MERVAT SAYED KAMAL SAYED · Jul 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a special kind of imaging called musculoskeletal ultrasound can help detect early inflammation in the joints of people with systemic lupus erythematosus (SLE), a condition where the immune system attacks the body. Many people with SLE experience joint pain, but sometimes this pain happens even when doctors can’t see clear signs of joint inflammation during a regular exam. This study aims to see if ultrasound can find hidden inflammation early on and whether these findings relate to how active the disease is, as well as a specific blood test called the neutrophil-to-C3 ratio, which may help show disease activity.

The study is open to adults with SLE who do not currently have obvious joint symptoms. To join, participants must have a confirmed SLE diagnosis based on established guidelines, and they should not have other conditions that affect their joints, like rheumatoid arthritis overlap, recent injuries, or surgeries in their hands or wrists. If you take part, you can expect to have an ultrasound scan of your joints to check for inflammation, along with blood tests to measure disease activity. This research might help doctors better understand and manage SLE by identifying joint problems earlier, even before symptoms appear.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • SLE patients without musculoskeletal manifestations diagnosed according to European League against Rheumatism (EULAR) and the American college of Rheumatology (ACR)criteria for classification of SLE.
• Exclusion Criteria:
• • • Overlap syndrome as rhupus patients, those with trauma, osteoarthritis, surgery of hand and wrist