Effectivity and Safety of GB20 Acupoint Pharmacopuncture With Lidocaine 2% on Migraine Patients

Launched by INDONESIA UNIVERSITY · Jul 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to treat migraines using a treatment called pharmacopuncture, where a small amount of 2% Lidocaine (a local anesthetic) is injected at a specific acupuncture point on the neck called GB20. The researchers want to find out if this treatment can reduce how often migraines happen, how long they last, how severe the pain is, and how much migraines affect daily life, compared to a common migraine medicine called propranolol. They will also check if the injections are safe and if they cause any side effects.

Adults who have been diagnosed with migraines and have at least three migraine days in a month may be eligible to join, as long as they don’t have other serious health issues like heart disease, asthma, or allergies to the study medicines. Participants will either receive weekly Lidocaine injections at the acupuncture point for four weeks or take propranolol pills twice a day for 28 days. They will also get paracetamol (Tylenol) to use if a migraine attack happens during the study. Throughout the two-month study, participants will use a headache diary app to track their migraines and fill out questionnaires about how migraines affect their daily life. The study will carefully watch for any side effects to ensure safety. This trial is not yet recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosed with migraine
• • Minimum of 3 days of migraine attacks in 1 month
• • Willing to participate until the study concludes
• Exclusion Criteria:
• • Headache with other known cause (e.g. head trauma, cancer, hemorrhagic stroke)
• • Inaccessible GB20 acupuncture point (scar tissue, infection, open wound, etc)
• • History of heart disease and/or asthma
• • History of Hypersensitivity with propranolol and/or lidocaine
• • History of acupuncture treatment 3 month prior to study
• • Routine consumption of anticoagulation medications, steroids or pain killers
• • Pregnant and breastfeeding women