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Search / Trial NCT07069127

Hydroxyapatite-Based Home Treatment for Dentin Sensitivity in Celiac Patients

Launched by UNIVERSITY OF PAVIA · Jul 5, 2025

Trial Information

Current as of July 23, 2025

Not yet recruiting

Keywords

Celiac Disease Dentin Hypersensitivity Enamel Demineralization Hydroxyapatite Remineralizing Agents Biorepair Toothpaste Oral Mousse Dental Sensitivity Randomized Controlled Trial

ClinConnect Summary

This clinical trial is studying a new home treatment to help reduce tooth sensitivity and improve enamel health in adults with celiac disease. People with celiac disease often have weaker tooth enamel and sensitive teeth, which can cause discomfort. The study will compare two groups: one using a special toothpaste containing hydroxyapatite (a mineral that helps repair teeth) twice a day, and the other using the same toothpaste plus a hydroxyapatite mousse applied once every evening. The researchers want to see if adding the mousse provides extra benefits in reducing sensitivity and strengthening the teeth over a 6-month period.

Adults aged 18 or older with diagnosed celiac disease, who have enamel problems, active tooth decay, and sensitive teeth, may be eligible to join. Participants will need to follow the treatment routine at home and attend check-ups at the start, then after 1 week, 1 month, 3 months, and 6 months. During these visits, dentists will check tooth sensitivity, plaque buildup, gum health, and signs of tooth decay using special tools and simple tests. The study has not started recruiting yet, but it aims to find out if this easy-to-use home treatment can help people with celiac disease protect their teeth and reduce discomfort.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adults (≥18 years of age) with a confirmed diagnosis of celiac disease.
  • Presence of enamel defects (hypomineralization or demineralization).
  • Presence of active carious lesions.
  • Self-reported dentin hypersensitivity.
  • Willingness to comply with the study protocol and follow-up schedule.
  • Written informed consent provided.
  • Exclusion Criteria:
  • Age below 18 years.
  • Absence of confirmed celiac disease.
  • Poor compliance or low motivation to participate in a 6-month study.
  • Ongoing treatment with products affecting enamel mineralization.
  • Pregnancy or breastfeeding.
  • Participation in another clinical trial within the previous 30 days.

About University Of Pavia

The University of Pavia, a prestigious institution renowned for its commitment to academic excellence and research innovation, serves as a prominent clinical trial sponsor. With a strong emphasis on advancing medical knowledge and improving patient care, the university leverages its multidisciplinary expertise and state-of-the-art facilities to conduct rigorous clinical research. Collaborating with leading healthcare professionals and institutions, the University of Pavia is dedicated to exploring novel therapeutic approaches and fostering the translation of scientific discoveries into clinical practice, ultimately aiming to enhance health outcomes and contribute to the global medical community.

Locations

Pavia, Lombardy, Italy

Patients applied

0 patients applied

Trial Officials

Andrea Scribante, Associate Professor

Principal Investigator

University of Pavia

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported