Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood Parameters
Launched by USKUDAR UNIVERSITY · Jul 5, 2025
Trial Information
Current as of July 22, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring whether there is a connection between gum disease (called periodontitis) and Alzheimer’s disease, focusing on how certain blood tests might help understand this relationship. Researchers want to see if inflammation in the gums is linked to changes in the blood that could also relate to Alzheimer’s, a condition that affects memory and thinking.
People who might join the study are adults over 50 years old who have been diagnosed with periodontitis and, if applicable, Alzheimer’s disease. They should not smoke or drink alcohol regularly, should not have mental health conditions or medicines that affect thinking, and must have had a recent blood test. Participants will undergo thorough dental and cognitive exams performed by experts. The study is not yet recruiting, and those interested would be seen at specific university dental clinics in Turkey. This research could help us better understand how oral health and brain health are connected.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Between March 2022 and July 2025, those who applied to the Periodontics Departments of the Dentistry Faculties of Uskudar University, Bezmialem Vakif University and Bolu Abant Izzet Baysal University,
- • Informed consent form was obtained during the examination,
- • Over 50 years of age,
- • Non-smoker and non-alcoholic,
- • No psychiatric disorders affecting cognitive status and no medication affecting cognitive status,
- • Complete blood count was performed within the 6 months prior to the date of inclusion in the study,
- • No dental treatment within the last 1 year,
- • Periodontal examination was performed by expert periodontologists who calibrated the inter- and intra-examination,
- • Individuals diagnosed with periodontitis as a result of periodontal examination and radiographic examination, and
- • For individuals diagnosed with Alzheimer's disease: Recording their stage according to the Clinical Dementia Rating (CDR) and Standardized Mini-Mental Test (SMMT) scores
- Exclusion Criteria:
- • Individuals with fewer than 10 teeth,
- • Individuals with uncontrolled systemic disease,
- • Individuals who regularly use anti-inflammatories or corticosteroids
About Uskudar University
Uskudar University is a distinguished academic institution located in Istanbul, Turkey, renowned for its commitment to advancing research and innovation in the fields of psychology, health sciences, and social sciences. As a clinical trial sponsor, Uskudar University leverages its extensive network of experts and cutting-edge facilities to conduct rigorous clinical research aimed at improving patient outcomes and contributing to the global body of scientific knowledge. The university emphasizes ethical research practices and collaboration with healthcare professionals, ensuring that its trials are designed to adhere to the highest standards of safety and efficacy. Through its clinical research initiatives, Uskudar University seeks to foster advancements in medical science and enhance the well-being of diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
OZLEM GELISIN
Study Chair
Dr. Sadi Konuk Training and Research Hospital
AHMET AYDOGDU
Study Chair
Private Galata Polyclinic
SADIYE GUNPINAR
Study Chair
Bezmialem Vakif University
ZEYNEP AKGUL
Study Chair
Abant Izzet Baysal University
AKCAN AKKAYA
Study Chair
Abant Izzet Baysal University
KUBRA KARADURAN
Principal Investigator
Uskudar University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported